Examine This Report on Superantigen - Wikipedia

Endogenous Droops [edit] Small lymphocyte stimulating (Mls) exotoxins were originally discovered in the thymic stromal cells of mice. These toxic substances are encoded by SAg genes that were included into the mouse genome from the mouse mammary tumour infection (MMTV). The presence of these genes in the mouse genome permits the mouse to reveal the antigen in the thymus as a means of negatively picking for lymphocytes with a variable Beta region that is vulnerable to stimulation by the viral Droop.

Comparable endogenous SAg-dependent selection has yet to be recognized in the human genome, but endogenous SAgs have actually been discovered and are believed of playing an important role in viral infection. Infection by the Epstein, Barr infection, for instance, is known to cause production of a SAg in contaminated cells, yet no gene for the toxic substance has been discovered on the genome of the infection.

superantigens - YouTube

Comparable results have actually been found with rabies, cytomegalovirus, and HIV. Recommendations [edit] Llewelyn M, Cohen J (March 2002). "Superantigens: microbial agents that corrupt immunity". Lancet Infect Dis. 2 (3 ): 15662. doi:10. 1016/S1473 -3099( 02 )00222-0. PMID 11944185. Li H., Llera A., Malchiodi E.L., Mariuzza R.A. The structural basis of T cell activation by superantigens.

Rev. Immunol. 1999; 17:435466. doi: 10. 1146/annurev. immunol. 17. 1.435. Sriskandan S, Faulkner L, Hopkins P (2007 ). "Streptococcus pyogenes: Insight into the function of the streptococcal superantigens". Int. J. Biochem. Cell Biol. 39 (1 ): 129. doi:10. 1016/j. biocel. 2006. 08.009. PMID 17029999. Mehindate K, Thibodeau J, Dohlsten M, Kalland T, Skaly RP, Mourad W (November 1995).

Comparison between the binding of a normal antigen and the binding of a  - Download Scientific Diagram

The Ultimate Guide To Superantigen - UniProt

J. Exp. Med. 182 (5 ): 15737. doi:10. 1084/jem. 182.5. 1573. PMC. PMID 7595227. Papageorgiou Air Conditioning, Tranter HS, Acharya KR (March 1998). "Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1. 5 A resolution: ramifications for superantigen acknowledgment by MHC class II molecules and T-cell receptors". J. Mol. Biol.

Persistence of Staphylococcus aureus on mucosal membranes: Superantigens  and internalization by host cells - The Journal of Laboratory and Clinical  Medicine

doi:10. 1006/jmbi. 1997.1577. PMID 9514739. Schlievert PM (April 1982).  Rosetta Enzoimmune  of host vulnerability to deadly endotoxin shock by staphylococcal pyrogenic exotoxin type C". Contaminate. Immun. 36 (1 ): 1238. doi:10. 1128/IAI.36. 1.123-128. 1982. PMC. PMID 7042568. Alouf JE, Mller-Alouf H (February 2003). "Staphylococcal and streptococcal superantigens: molecular, biological and scientific aspects".